In chromatographic analysis, the number of repeated measurements is often limited due to time, cost, and sample availability constraints. It is therefore not uncommon for chromatographers to do a single measurement.

Protecting your network chromatography data system (CDS) data is critical and a service level agreement (SLA) with your IT provider is vital. What should be included? Are SLAs for in-house IT and SaaS (software as a service) similar?

LCGC International spoke to Lauren Lovejoy, principal scientist in the Drug Substance and Product Analysis group at GSK (Philadelphia, Pennsylvania), about the advantages of using tandem columns in sequential elution liquid chromatography (SE-LC) to investigate weak acids, neutral compounds, and permanent anions in pharmaceutical applications.

In this installment, we will review the fundamental terminology and data analysis principles in benchtop GC–MS. We will compare the three modes of analysis—full scan, extracted ion chromatograms, and selected ion monitoring—and see how each is used for quantitative and quantitative analysis.

In this installment of “LC Troubleshooting,” Dwight Stoll touches on highlights from Pittcon 2025 talks, as well as troubleshooting advice distilled from a lifetime of work in separation science by LCGC Award winner Christopher Pohl.

With green chemistry becoming more standardized, Leena Pitkänen of Aalto University analyzed how useful size-exclusion chromatography (SEC) and asymmetric flow field-flow fractionation (AF4) could be in characterizing plant polysaccharides.

In part 2, Ralph Mead and his team explain the challenges of characterizing and quantifying PFAS in environmental samples.

Here is some of the most popular content posted on LCGC International this week.

The Mead Group at UNC Wilmington studies the occurrence and transport PFAS in wet and dry depositions, tracing their sources to inform regulators. In the first part of our interview, we spoke with Mead and several members of his team about the work they do for the North Carolina PFAS Testing Network and learn more about the network.

In this final part of our interview with Ezgi Gürler of Females in Mass Spectrometry, we ask about her upcoming research that will occur during her tenure at DESY-CSSB and Uppsala University.

Researchers attempted to ascertain the relationship between vitamin D levels in athletes and the structural and functional values of their hearts assessed through electrocardiographic and echocardiographic parameters. Vitamin D levels were measured using high performance liquid chromatography–tandem mass spectrometry (HPLC–MS/MS).

In this second part of our interview with Ezgi Gürler of Females in Mass Spectrometry, we ask about her time at BIOCEV developing advanced fragmentation schemes for non-covalent complexes and Norovirus P-dimer proteins.

In this first roundtable discussion focused on Women in Chromatography, LCGC International spoke with Diane Turner, Jacqueline Hamilton, and Caroline Gauchotte-Lindsay, who discussed emerging trends in chromatography and useful resources for women in chromatography.

Frankincense essential oil is known for its anti-inflammatory, antioxidant, and therapeutic properties. A recent study investigated the protective effects of the oil in an excision wound model in rats, focusing on oxidative stress reduction, inflammatory cytokine modulation, and caspase-3 regulation; chemical composition of the oil was analyzed using gas chromatography–mass spectrometry (GC–MS).

Researchers from KU Leuven explored two-dimensional liquid chromatography (2D-LC)’s application to profile micropollutants in wastewater.